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KMID : 1146920200500010017
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Journal of Pharmaceutical Investigation
2020 Volume.50 No. 1 p.17 ~ p.27
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Solubility enhancement and application of cyclodextrins in local drug delivery
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Kim Dong-Hyun
Lee Sang-Eun
Pyo Yong-Chul
Tran Phuong
Park Jeong-Sook
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Abstract
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Cyclodextrins (CDs) have been used in many pharmaceutical formulations as their constitution and inherent shape present advantages for drugs with poor aqueous solubility and low bioavailability. Because CDs can act as drug carriers by forming inclusion complexes to conjugate with many drugs, they have been applied in many drug delivery systems and can be used to develop new strategies. The objectives of this review are to describe the role of CDs in local administration, the ways in which CDs are used, and relevant studies currently underway. The basic structure and characteristics of CDs, as well as the mechanisms used to formulate inclusion complexes to solubilize drugs are also described. Several studies have been conducted to investigate the use of CDs and most have shown improvements in drug solubility and bioavailability. CDs show potential not only in the pharmaceutical industry but also in a variety of applications, and further research into the use of other drug carriers is therefore necessary.
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KEYWORD
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Cyclodextrin, Inclusion complex, Local administration, Drug delivery, Drug carrier
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